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Genetic link found to emotional sensitivity in stressful situations

In a recent study published in Scientific Reports, researchers assess how genetic variation in a cluster of differentiation 38 (CD38) is related to increased personal distress in an emotionally evocative situation. 

Study: CD38 genetic variation is related to increased personal distress to an emotional stimulus. Image Credit: Dragana Gordic /

CD38 and oxytocin

Oxytocin is a peptide neurohormone that’s actively involved in social behavior, including parent-infant bonding, particularly within the immediate period following childbirth, romantic relationships, and group dynamics. Oxytocin-related genetic variants have been related to various effects on empathy, brain activation during emotion recognition tasks, responses to trauma, and the danger of autism.

Recently, researchers have identified that A allele carriers of the CD38 single nucleotide polymorphism (SNP) rs3796863 had higher plasma oxytocin levels, a more sensitive approach to parenting, and stronger empathic responses. Nonetheless, other studies have reported that students with the AA genotype of the CD38 SNP reported higher levels of suicide ideation, depressive symptoms, and greater alienation from parents and peers.

These conflicting findings have led some researchers to theorize that A carriers could also be more socially sensitive, which, consequently, could lead on to a stronger negative emotional response during stressful situations. Despite this idea, no study so far has assessed the impact of the CD38 genotype on negative reactivity to an emotionally stressful situation.

Concerning the study

For the current study, researchers recruited Canadian university students 18 years of age and older with no health issues expected to influence hormone levels. All study participants were shown a three-minute video depicting a father narrating the story of his child’s terminal cancer.

After the video, study participants accomplished a questionnaire in search of to evaluate their emotional response to 12 emotions, six of which involved feelings of empathic concern, whereas the remaining six included feelings of private distress. These responses were rated on a scale from one to 5, with higher scores indicating higher endorsement of the emotional response. 

Two Interpersonal Reactivity Index (IRI) subscales, including the non-public distress and empathic concern subscales, were used to explore whether the CD38 genotype related to dispositional measures of emotional responses. Participants accomplished the IRI roughly 10 minutes after watching the emotional video, during which they rated their responses on a five-point Likert scale, with the next rating indicating increased empathy.

Study findings

A complete of 171 students participated in the present study, 24, 77, and 70 of whom had the AA, AC, and CC genotypes of the CD38 SNP, respectively. 

The typical distress-related response rankings were higher for females than males and AA/AC than CC genotypes, thus suggesting that sex and CD38 genotype affected these responses but not their interaction. Females also scored higher than males on empathy-related responses; nonetheless, these scores weren’t significantly different amongst different genotypes.

On each IRI subscales, sex had a big effect, with females scoring higher than males. Nonetheless, the IRI subscale results weren’t significantly different between the CD38 genotypes.

When seeing someone in distress, individuals with the A allele reported insignificant levels of empathy, a well-recognized response of care, but markedly higher levels of private distress, a self-focused emotional response. 

An empathy-inducing situation may elicit these two responses concurrently; nonetheless, they will have different consequences. For instance, while empathy promotes helping behavior to alleviate the distress of the person in need, an individual in distress can have the urge to alleviate their very own distress slightly than offer help to the opposite person in need of help.


The present study provides preliminary evidence that genetic variation in CD38 influences social-emotional sensitivity. To this end, A allele carriers were more vulnerable to distress-related emotions in response to a negative social stressor. 

The study findings may reconcile paradoxical findings that CD38 A allele carriers are more empathetic despite exhibiting worse interpersonal outcomes. Despite having greater empathy, their high levels of private distress may prevent appropriate social support from being provided when involved in social conflict. 

This data on oxytocin-related genetic variants could possibly be used to predict individuals for whom the buffer against stress and anxiety in response to difficult interpersonal situations is weaker. Given their inability to control their negative emotions, these individuals should receive adequate and timely support.

Future studies, especially in interpersonal contexts, need to make use of more natural empathy paradigms to evaluate the role of CD38 in emotional regulation.

Journal reference:

  • Procyshyn, T. L., Leclerc Bédard, L., Crespi, B. J., & Bartz, J. A. (2024). CD38 genetic variation is related to increased personal distress to an emotional stimulus. Scientific Reports 14(1); 1-7. doi:10.1038/s41598-024-53081-5
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