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Research opens the door to a possible treatment strategy for certain advanced prostate cancers

Summary: Epigenetic changes may cause prostate cancer to withstand treatment by switching genes on or off. One epigenetic mechanism tags genes with DNA methylation marks. This process is mediated by molecules called DNA methyltransferases. These tags can alter gene expression in ways in which promote tumors to grow and transition into advanced types of the disease. Researchers from Dana-Farber Cancer Institute discovered, in experiments using patient-derived preclinical models of advanced prostate cancer, that inhibition of DNA methylation with decitabine, a drugs utilized in the treatment of certain blood cancers, slows tumor growth specifically in a subset of advanced prostate cancers which have neuroendocrine features or lack of the gene RB1. It also leads to decreased methylation and elevated expression of a gene that produces a receptor called B7-H3. This receptor is the goal of an antibody-drug conjugate currently in evaluation in clinical trials called DS-7300a. In prostate cancers with high levels of B7-H3, DS-7300a was effective by itself. Nevertheless, DS-7300a alone was less effective when B7-H3 levels are low. The researchers observed that when the drugs are combined, decitabine sensitizes tumors to DS-7300a and improves efficacy.

Impact: Patients with advanced prostate cancer with tumors harboring RB1 gene loss or neuroendocrine features often have a poor prognosis and limited treatment options. This research opens the door to a possible treatment strategy geared specifically toward this population that involves decitabine, B7-H3 targeted therapy, or the 2 together.

Funding: This research was supported by the Japan Society for the Promotion of Science, the Prostate Cancer Foundation, the US Department of Defense, the National Cancer Center, the National Institutes of Health, and Daiichi Sankyo.


Journal reference:

Yamada, Y., et al. (2023). Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer. Science Translational Medicine. doi.org/10.1126/scitranslmed.adf6732.

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