INFERTILITY AND MENTAL HEALTH
PSYCHIATRIC ILLNESS DURING PREGNANCY
Mefrouche ML, Siegmann EM, Böhme S, Berking M, Kornhuber J. Eur J Investig Health Psychol Educ. 2023 Sep 1;13(9):1694-1706.
This systematic review and meta-analysis of randomized-controlled trials investigates the effect of digital-based mindfulness interventions on depressive, anxiety, and stress symptoms while pregnant. Digital mindfulness intervention methods were significantly in a position to reduce depression and anxiety symptoms, but not stress symptoms.
MEDICATIONS AND PREGNANCY
Holmes LB, Quinn M, Conant S, Lyons A, Hauser WA, Yerby M, Hernandez-Diaz S. Birth Defects Res. 2023 Aug 15;115(14):1274-1283.
Werler MM, Kerr SM, Ailes EC, Reefhuis J, Gilboa SM, Browne ML, Kelley KE, Hernandez-Diaz S, Smith-Webb RS, Garcia MH, Mitchell AA; National Birth Defects Prevention Study and Birth Defects Study To Evaluate Pregnancy exposures.Clin Pharmacol Ther. 2023 Oct;114(4):836-844.
The researchers analyzed data from 9,755 women whose infants served as controls in two large United States case-control studies from 1997-2011 and 2014-2018. After excluding vitamin, herbal, mineral, vaccine, i.v. fluid, and topical products and over-the-counter medications, the proportion of girls that reported taking at the least one prescription medication in the primary trimester increased over the study years, from 37% to 50% of girls. The corresponding proportions increased with increasing maternal age and years of education, were highest for non-Hispanic White women (47%) and lowest for Hispanic women (24%). Probably the most common indication for first trimester use of a drugs was infection (12-15%). Increases were observed across the years for medications used for indications related to nausea/vomiting, depression/anxiety, infertility, thyroid disease, diabetes, and epilepsy.
POSTPARTUM PSYCHIATRIC ILLNESS
Alcantarilla L, López-Castro M, Betriu M, Torres A, Garcia C, Solé E, Gelabert E, Roca-Lecumberri A. Arch Womens Ment Health. 2023 Sep 18.
Recurrences of BD and rMDD are more frequent within the postpartum period than in pregnancy, with the primary 4-6 weeks postpartum being especially complicated. As well as, women with BD type I are at higher risk than those with BD type II and rMDD, and probably the most frequent presentation of perinatal episodes of each disorders is a serious depressive episode. Other risk aspects consistently repeated were early age of onset of illnesses, severity criteria, primiparity, abrupt discontinuation of treatment, and private or family history of perinatal affective episodes.
Obichili MI, Ogwo CA, Udeh K, Obiechina CK, Kakwagh VV, Eze CC, Gever VC. Health Care Women Int. 2023 Aug 10:1-18. The study demonstrated a major primary effect of social media-based psychodrama therapy in reducing symptoms of postpartum depression in women. The study also found that this relationship is moderated by spousal support like physical, emotional and social support.
Janssen LE, Laarman ARC, van Dijk-Lokkart EM, Bröring-Starre T, Oudijk MA, de Groot C, Boer M. Am J Perinatol. 2023 Sep 27.
After a median of 13 years after delivery, no significant differences were present in prevalence or severity of tension or depressive symptoms. Nevertheless, significantly more women with a history of spontaneous preterm birth reported that the birth still had an impact on each day life; aOR 2.46, (95% CI: 1.35-4.48). A complete of 57 (16.3%) women after SPTB reported to have needed skilled psychosocial support after delivery but didn’t receive it.
Zhang S, Lu B, Wang G. Ann Gen Psychiatry. 2023 Sep 27;22(1):36.
Compared with women without lactational mastitis, the proportion of girls with depression symptoms was significantly higher (38.1% vs. 27.4%, p = 0.008), and the danger of postpartum depression increased by 68% (RR = 1.68, 95% CI, 1.18, 2.40) in women who had experienced lactational mastitis. As well as, the danger of self-harm or suicidal ideation increased by 89% (RR = 1.89, 95% CI, 1.08, 3.29) in women who experienced lactational mastitis.
MEDICATIONS AND BREASTFEEDING
PERINATAL SUBSTANCE USE
MATERNAL MENTAL HEALTH AND CHILD OUTCOMES
Biaggi A, Hazelgrove K, Waites F, Bind RH, Lawrence AJ, Fuste M, Conroy S, Howard LM, Mehta MA, Miele M, Seneviratne G, Pawlby S, Pariante CM, Dazzan P. Psychol Med. 2023 Sep 14:1-12.
Women susceptible to postpartum psychosis (PP) as a gaggle, no matter whether or not they developed a psychiatric relapse inside 4 weeks after delivery, had less synchronous mother-infant interactions and had infants with less optimal cognitive, language, motor and socio-emotional development than healthy controls. Specifically, boys of at-risk women had the bottom scores in cognitive, language and motor development and in mother-infant interaction, while girls of the at-risk women had the bottom scores in socio-emotional development. The synchrony within the dyad predicted infant cognitive and language development. There was no evidence for a difference in mother-infant interaction nor in infant development between the at-risk-unwell and at-risk-well groups.
Findings suggest that FHR variability could also be an early precursor of infant self-regulation that underlies the association between mother’s prenatal depressive symptoms and infant self-regulation. Infants of moms with higher levels of prenatal depressive symptoms may very well be susceptible to self-regulation problems, partially because of their lower FHR variability.
This study suggests that increasing maternal depressive symptoms over the perinatal period is related to poorer executive function (EF) outcomes in children at age 4 – independent of prenatal smoking, drinking, or antidepressant use. Depressive chronicity, severity, and postpartum influences may play crucial roles in determining childhood outcomes of EF.
Dias CC, Pinto TM, Figueiredo B. Behav Sleep Med. 2023 Nov 2;21(6):695-711.
While controlling for maternal postnatal depressive symptoms, our results revealed that (1) infant negative affectivity at two weeks partially mediated the impact of maternal prenatal depressive symptoms on sleep anxiety at six months, and (2) this mediation is independent of the infant’s sex.
Phua DY, Chew CSM, Tan YL, Ng BJK, Lee FKL, Tham MMY. Front Pediatr. 2023 Sep 14;11:1221232.
This meta-analysis, comprising 74 studies with 321,966 mother-child dyads across 21 countries, revealed significant associations of prenatal psychological distress with each opposed and positive child socioemotional outcomes. Notably, the effect sizes for the association of psychological distress with positive child outcomes were smaller in comparison with opposed outcomes. Positive prenatal mental health, then again, was significantly related to positive socioemotional outcomes but not opposed outcomes.
MENOPAUSE AND MENTAL HEALTH
OTHER TOPICS IN WOMEN’S MENTAL HEALTH
Thompson SM. Neuropsychopharmacology. 2023 Sep 14.