PMS AND PMDD
Stiernman L, Dubol M, Comasco E, Sundström-Poromaa I, Boraxbekk CJ, Johansson M, Bixo M. Transl Psychiatry. 2023 Apr 14;13(1):124.
ndividuals with PMDD show altered emotion-induced brain responses within the late-luteal phase of the menstrual cycle which could also be related to an abnormal response to physiological levels of GABAA-active neurosteroids.
INFERTILITY AND MENTAL HEALTH
PSYCHIATRIC ILLNESS DURING PREGNANCY
Lupattelli A, Corrao G, Gatti C, Rea F, Trinh NTH, Cantarutti A. J Affect Disord. 2023 Jul 16;339:502-510.
This study found no difference in risk for antenatal hospitalization for depression/anxiety in women who continued antidepressant while pregnant or who had higher levels of adherence in pregnancy, relative to discontinuation or lower adherence. It’s difficult to interpret these results provided that the ladies who elect to proceed medication while pregnant are clinically distinct from those that elect to discontinue medication.
Muskens L, Hulsbosch LP, van den Heuvel MI, Croes EAJ, Kop WJ, Pop VJM, Boekhorst MGBM. J Affect Disord. 2023 Oct 1;338:495-501.
Three trajectories of depressive symptoms while pregnant were identified: a low stable (N = 489, 70.2 %), intermediate stable (N = 183, 26.3 %), and high stable (N = 25, 3.6 %) class. SMU Time and Frequency were significantly related to belonging to the high stable class. Problematic SMU was significantly related to belonging to the intermediate or high stable class.
Palagini L, Cipriani E, Miniati M, Bramante A, Gemignani A, Geoffroy PA, Riemann D. J Sleep Res. 2023 Jul 13:e14000.
The outcomes of the meta-analysis indicated that insomnia and poor sleep quality increase the chances of suicidal risk in pregnant women by greater than threefold (OR = 3.47; 95% CI: 2.63-4.57). Specifically, the chances ratio (OR) for poor sleep quality was 3.72 (95% CI: 2.58-5.34; p < 0.001), and for insomnia symptoms, after bearing in mind perinatal depression, was 4.76 (95% CI: 1.83-12.34; p < 0.001).
Stefana A, Langfus JA, Palumbo G, Cena L, Trainini A, Gigantesco A, Mirabella F. Arch Womens Ment Health. 2023 Jul 18.
This study suggests that the EPDS needs to be preferred to PHQ-9 for measuring depressive symptoms in peripartum populations.
Sominsky L, O’Hely M, Drummond K, Cao S, Collier F, Dhar P, Loughman A, Dawson S, Tang ML, Mansell T, Saffery R, Burgner D, Ponsonby AL, Vuillermin P; Barwon Infant Study Investigator Group. Brain Behav Immun. 2023 Jul 10;113:189-202.
Pre-pregnancy obesity increases the danger of antenatal depressive symptoms and can also be related to systemic inflammation while pregnant. While discrete inflammatory markers are related to antenatal depressive symptoms and perceived stress, their role in mediating the consequences of pre-pregnancy obesity on antenatal depression requires further investigation.
Echabe-Ecenarro O, Orue I, Cortazar N. J Reprod Infant Psychol. 2023 Jul 17:1-14.
Pregnant women, especially those that have suffered a previous prenatal loss and rating high in neuroticism or low in extraversion, may profit from interventions that enhance social support.
MEDICATIONS AND PREGNANCY
Robakis TK, Miyares S, Bergink V. Acta Psychiatr Scand. 2023 Jul 8.
Greater reductions in maternal antidepressant dose just prior to delivery were related to fewer admissions to the neonatal intensive care unit (NICU) for infants. There was a rather greater increase in depressive symptoms across delivery for girls who tapered, which was not statistically significant.
POSTPARTUM PSYCHIATRIC ILLNESS
Yang SQ, Zhou YY, Yang ST, Mao XY, Chen L, Bai ZH, Ping AQ, Xu SY, Li QW, Gao K, Wang SY, Duan KM. J Affect Disord. 2023 Jul 11;339:333-341.
Esketamine (0.25 mg kg-1) intravenous infusion combined with 1 mg kg-1 or 2 mg kg-1 esketamine PCIA seems secure and with few adversarial effects within the management of PDS and pain in women undergoing cesarean section.
Li Q, Gao K, Yang S, Yang S, Xu S, Feng Y, Bai Z, Ping A, Luo S, Li L, Wang L, Shi G, Duan K, Wang S. J Affect Disord. 2023 Jul 13;339:264-270.
Logistic regression and machine learning algorithms could possibly be used to predict the effectiveness of IV ketamine/esketamine through the course of cesarean section for PPD prevention. An individualized preventative strategy could possibly be developed after entering individuals’ clinical features into the model, which could be of great clinical value when it comes to reducing PPD incidence.
Sharma V, Sharkey KM, Palagini L, Mazmanian D, Thomson M. Expert Rev Neurother. 2023 Jul 18:1-9.
Targeting disturbed and/or insufficient sleep – a typical and early transdiagnostic symptom of peripartum psychiatric disorders – could also be a simpler intervention for the prevention of postpartum depression and psychiatric comorbidities in some individuals than the normal approach of antidepressant use.
Hidalgo-Padilla L, Toyama M, Zafra-Tanaka JH, Vives A, Diez-Canseco F. Arch Womens Ment Health. 2023 Jul 17.
Paid and longer maternity leaves are likely to be related to a discount of postpartum depression symptoms in high-income countries. No studies explored the association between employment protection and postpartum depression.
Caruso S, Caruso G, Bruno MT, Minona P, Di Guardo F, Palumbo M. Eur J Obstet Gynecol Reprod Biol. 2023 Jul 6;288:73-77.
Drospirenone (DRSP) only pill (DOP) 4 mg, in a 24 lively/4 placebo regimen, appeared to modulate risk of postpartum depression.
Jaramillo I, Karl M, Bergunde L, Mack JT, Weise V, Weidner K, Gao W, Steudte-Schmiedgen S, Garthus-Niegel S. J Affect Disord. 2023 Jul 15;339:974-983.
These results suggest that negative objective birth experience is related to an altered hair cortisol to cortisone ratio (HairF/HairE), which in turn, appears to be a promising biomarker to discover women in danger for developing PPD. A negative subjective birth experience could also be less critical for alterations of the HPA-axis but stays a vital risk factor for PPD.
Wang X, Qiu Q, Shen Z, Yang S, Shen X. J Affect Disord. 2023 Jul 16;339:823-831.
Interpersonal psychotherapy was effective for the treatment of depression in patients with postpartum depression, but the suitable time of intervention was between 4 and eight weeks. IPT also improved satisfaction with the family of patients, and the longer the intervention, the upper the satisfaction.
Aviv EC, Preston EG, Waizman YH, Dews AA, Flores G, Saxbe DE. J Affect Disord. 2023 Jul 17;339:593-600.
Fathers’ rankings of subjective birth stress significantly predicted postpartum depressive symptoms at six months postpartum. Subjective birth stress rankings varied significantly for fathers whose partners delivered via emergency cesarean section in comparison with those whose partners gave birth via each medicated and the unmedicated vaginal delivery.